KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.

Blood 2014 Oct 12;124(17):2744-7. Epub 2014 Aug 12.

Children's Hospital, University of Tübingen, Germany;

We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score.

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http://dx.doi.org/10.1182/blood-2014-03-565069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208288PMC
October 2014
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References

(Supplied by CrossRef)
The extensive polymorphism of KIR genes.
Middleton et al.
Immunology 2010

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