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Brain Stimul 2018 Jan - Feb;11(1):104-107. Epub 2017 Sep 28.

Biomedical Engineering Department, Amirkabir University of Technology, Tehran, Iran.

Despite increasing attention to the application of transcranial Direct Current Stimulation (tDCS) for enhancing cognitive functions in subjects exposing to varying degree of cerebral atrophy such as Alzheimer's disease (AD), aging, and mild cognitive impairment (MCI), there is no general information for customizing stimulation protocol.

Objective: The objective of this study is to examine how cerebral shrinkage associated with cognitive impairment and aging can perturb current density distribution through the brain.

Methods: We constructed three high-resolution human head models representing young, elder, and MCI subjects and modeled two electrode configurations using rectangular electrodes. Read More

Trials 2017 06 19;18(1):285. Epub 2017 Jun 19.

Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, Japan.

Background: Patients with Alzheimer's disease frequently elicit neuropsychiatric symptoms as well as cognitive deficits. Above all, depression is one of the most common neuropsychiatric symptoms in Alzheimer's disease but antidepressant drugs have not shown significant beneficial effects on it. Moreover, electroconvulsive therapy has not ensured its safety for potential severe adverse events although it does show beneficial clinical effect. Read More

Alzheimers Res Ther 2016 Mar 23;8(1):13. Epub 2016 Mar 23.

Department of Psychology, Research Group for Cognitive Neuroscience, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

Background: The purpose of this study was to assess the efficacy of transcranial direct current stimulation (tDCS) on verbal memory function in patients with Alzheimer's disease.

Methods: We conducted a randomized, placebo-controlled clinical trial in which tDCS was applied in six 30-minute sessions for 10 days. tDCS was delivered to the left temporal cortex with 2-mA intensity. Read More

Neuroimage Clin 2013 31;2:759-66. Epub 2013 May 31.

Neural Engineering Laboratory, Department of Biomedical Engineering, The City College of City University of New York, 160 Convent Ave, Steinman Hall, T-403B, New York, NY, USA.

Recent studies show that acute neuromodulation of the prefrontal cortex with transcranial direct current stimulation (tDCS) can decrease food craving, attentional bias to food, and actual food intake. These data suggest potential clinical applications for tDCS in the field of obesity. However, optimal stimulation parameters in obese individuals are uncertain. Read More