Maternal microchimerism: friend or foe in type 1 diabetes?

Chimerism 2014 ;5(2):21-3

Diabetes and Metabolism Unit; School of Clinical Sciences; University of Bristol; Bristol, UK.

Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic, supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199804PMC
http://dx.doi.org/10.4161/chim.29870DOI Listing
May 2015
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