Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Portopulmonary hypertension.

Ann Thorac Med 2014 Jul;9(Suppl 1):S42-6

Prince Sultan Medical Military City, Riyadh, Saudi Arabia.

Portopulmonary hypertension (POPH) is defined as pulmonary arterial hypertension (PAH) complicated by portal hypertension, with or without advanced hepatic disease. Significant percentage of patients with cirrhotic liver disease has high cardiac output and subsequently elevated pulmonary arterial pressures (PAP). However, patients with POPH develop a progressive increase in pulmonary vascular resistance (PVR), which is generally lower than that observed in other forms of PAH. The prognosis of untreated patients with POPH is very poor and the outcome of liver transplant (LT) in those patients is determined by the degree of severity of the associated pulmonary hemodynamics. In this narrative review, we describe the clinical presentation of POPH, the pathobiology, and the clinical implication of pulmonary hemodynamics. We also provide evidence-based recommendations for the diagnosic and management approaches of POPH.

Download full-text PDF

Source
http://dx.doi.org/10.4103/1817-1737.134021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114279PMC
July 2014
16 Reads

Publication Analysis

Top Keywords

patients poph
8
pulmonary hemodynamics
8
hypertension portopulmonary
8
pulmonary arterial
8
portopulmonary hypertension
8
pulmonary
6
hypertension
5
poph
5
presentation poph
4
increase pulmonary
4
subsequently elevated
4
pulmonary vascular
4
clinical presentation
4
describe clinical
4
resistance pvr
4
vascular resistance
4
progressive increase
4
develop progressive
4
clinical implication
4
arterial pressures
4

Similar Publications