Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery.

Authors:
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States

Adv Mater 2014 Sep 17;26(35):6174-80. Epub 2014 Jul 17.

Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1cc 1701, Place Eugène Bataillon, F-34095, Montpellier cedex 05, France.

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.

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http://dx.doi.org/10.1002/adma.201401931DOI Listing
September 2014
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