Do NIA-AA criteria distinguish Alzheimer's disease from frontotemporal dementia?

Alzheimers Dement 2015 Feb 9;11(2):207-15. Epub 2014 Jul 9.

Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK; Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK. Electronic address:

Background: Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies.

Objective: The aim was to assess the National Institute on Aging and Alzheimer's Association (NIA-AA) criteria for Alzheimer's disease (AD) dementia in AD and frontotemporal lobar degeneration (FTLD).

Methods: Two hundred twelve consecutive patients with pathologically confirmed AD or FTLD who were clinically assessed in a specialist cognitive unit were identified. Fifty-five patients were excluded predominantly because of insufficient clinical information. Anonymized clinical data were rated against the NIA-AA criteria by raters who were blinded to clinical and pathologic diagnosis.

Results: The NIA-AA AD dementia criteria had a sensitivity of 65.6% for probable and 79.5% for possible AD and a specificity of 95.2% and 94.0% for probable and possible, respectively.

Conclusion: In patients with FTLD and predominantly early-onset AD, the NIA-AA AD dementia criteria have high specificity but lower sensitivity. The high specificity is due to the broad exclusion criteria.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2014.04.516DOI Listing
February 2015
49 Reads

Publication Analysis

Top Keywords

nia-aa criteria
12
alzheimer's disease
8
high specificity
8
dementia criteria
8
nia-aa dementia
8
criteria
6
nia-aa
5
insufficient clinical
4
patients excluded
4
excluded insufficient
4
clinical anonymized
4
clinical data
4
criteria raters
4
rated nia-aa
4
data rated
4
fifty-five patients
4
anonymized clinical
4
cognitive unit
4
patients pathologically
4
pathologically confirmed
4

Similar Publications