Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer.

Polym Chem 2014 Jul;5(13):3977-3981

Departments of Chemistry, Chemical Engineering, and Materials Science and Engineering, Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. BOX 30012, 3255 TAMU, College Station, TX, 77842 (USA).

Sequential polymerization of -carboxyanhydrides accelerated by nitrogen flow is utilized to generate a novel well-defined diblock copolypeptide (PDI = 1.08), with incorporation of alkyne-functionalized side-chain groups allowing for rapid and efficient thiol-yne click-type modifications, followed by self-assembly into nanopure water to construct a helical polypeptide-based versatile and functional nanoparticle platform.

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Source
http://dx.doi.org/10.1039/C4PY00628CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084918PMC
July 2014

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