Is assessment of anti-Müllerian hormone and/or antral follicle count useful in the prediction of ovarian response in expected normal responders treated with a fixed dose of recombinant FSH and GnRH antagonists? A prospective observational study.

Authors:
Maria A Ganidou
Maria A Ganidou
Medical School
Christos A Venetis
Christos A Venetis
Aristotle University of Thessaloniki
Greece
Spiros Gerou
Spiros Gerou
Laboratories "Analysis"
Casale Monferrato | Italy
Georgios A Makedos
Georgios A Makedos
Aristotle University of Thessaloniki
Greece
Nikolaos Klearchou
Nikolaos Klearchou
Aristotle University of Thessaloniki
Greece
Basil C Tarlatzis
Basil C Tarlatzis
Aristotle University of Thessaloniki
Greece

Gynecol Endocrinol 2014 Nov 3;30(11):817-21. Epub 2014 Jul 3.

Unit for Human Reproduction, 1st Dept. of OB/Gyn, Medical School, Aristotle University of Thessaloniki , Greece .

The purpose of this prospective observational study was to evaluate whether the assessment of AMH and AFC is useful in the prediction of ovarian response in expected normal responders treated with a fixed dose of recombinant FSH (rec-FSH) and GnRH antagonists. A base model including age and basal FSH as independent predictors of COCs could explain 15% of the variance observed in the number of COCs retrieved (p = 0.002). The addition of AFC did not increase significantly the predictive ability of the above model, whereas the addition of AMH increased the performance of the base model by 13% (p < 0.001). Logistic regression analysis showed that only when AMH was added to the base model, including age and FSH, its predictive capacity for high ovarian response was statistically significant (F-test: p = 0.001; c-statistic: 0.80, 95% CI: 0.70-0.88), but this was not the case for poor ovarian response. In conclusion, the addition of AMH, but not of AFC, to a model including female age and basal FSH, is useful in the prediction of ovarian response in expected normal responders treated with a fixed dose of recombinant FSH and GnRH antagonists.

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http://dx.doi.org/10.3109/09513590.2014.938624DOI Listing

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November 2014
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