Kaposi's Varicelliform-Like Eruption in a Patient Treated with Everolimus for Metastatic Renal Cell Carcinoma: Report of a Rare Case.

Case Rep Oncol 2014 May 27;7(2):337-42. Epub 2014 May 27.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea ; Department of Institute for Cancer Research, Yonsei University College of Medicine, Seoul, Korea ; Department of Brain Korea 21 Project for Medical Science, Seoul, Korea.

Kaposi's varicelliform eruption is a cutaneous eruption caused by the herpes simplex virus and a few other viruses that infect persons with pre-existing dermatosis such as atopic dermatitis. We report the case of a 56-year-old man who was treated with the mammalian target of rapamycin inhibitor, everolimus, for metastatic renal cell carcinoma. He presented with painful, umbilicated vesicles and pustules on his face, genital region, forearms, and legs suggestive of Kaposi's varicelliform eruption. He did not have a history of any visceral viral disease and pre-existing dermatosis. The diagnosis was based on the clinical features. He was treated with acyclovir for 7 days, with improvement of his skin lesions. We discuss the clinical manifestations of the Kaposi varicelliform-like eruption in an immunocompromised patient treated with everolimus.

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http://dx.doi.org/10.1159/000362925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067721PMC
May 2014
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