Int J Clin Exp Pathol 2014 15;7(5):2430-7. Epub 2014 Apr 15.
Department of Pathology, Chi-Mei Medical Center Tainan, Taiwan ; Taipei Medical University and National Taiwan University Taipei, Taiwan.
Download full-text PDF
Leuk Lymphoma 2017 01 9;58(1):53-63. Epub 2016 May 9.
a Department of Pathology , Seoul National University Hospital, Seoul National University College of Medicine , Seoul , South Korea.
Epstein-Barr virus-positive T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) include several overlapping EBV-related conditions with variably aggressive courses. For prognostic categorization, we retrospectively analyzed 42 EBV-T/NK-LPD cases. Male (79% [33/42]), young (≤40 years; 83% [35/42]) patients and T-cell lineage (81% [34/42]; CD8/CD4 = 1. Read More
J Clin Virol 2011 May 5;51(1):31-7. Epub 2011 Mar 5.
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Background: In Japan, chronic active Epstein-Barr virus infection (CAEBV) may manifest with infection of T-cells or NK-cells, clonal lymphoid proliferations, and overt lymphoid malignancy. These EBV-positive lymphoproliferative disorders (EBV(+)LPD) of childhood are related to, but distinct from the infectious mononucleosis-like CAEBV seen in Western populations. The clonal nature of viral infection within lymphoid subsets of patients with EBV(+)LPD of childhood is not well described. Read More
Int J Oncol 2004 May;24(5):1165-74
First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan.
Epstein-Barr virus (EBV)-associated T/NK-cell lymphoproliferative disorders (LPD) of children and young adults are sometimes termed as severe chronic active EBV infection (CAEBV), and are associated with an aggressive clinical course. However, these clinicopathological states and the role of EBV have not been clarified. A retrospective study was performed on 43 children and adult patients, who manifested EBV-associated T/NK-cell lymphoproliferative disorders (EBV-T/NK-LPD) and most of whom had experienced general illness with CAEBV for several months or years. Read More
Pathol Int 2008 Apr;58(4):209-17
Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
EBV-associated T/natural killer (NK)-cell lymphoproliferative disorder (EBV-T/NK LPD) of children and young adults is generally referred to with the blanket nosological term of severe chronic active EBV infection (CAEBV). This disease is rare, associated with high morbidity and mortality, and appears to be more prevalent in East Asian countries. But because there is no grading or categorization system for CAEBV, pathologists and clinicians often disagree regarding diagnosis and therapy. Read More