Association of serum omentin-1 concentrations with the presence and severity of preeclampsia.

Ann Clin Biochem 2015 Mar 9;52(Pt 2):245-50. Epub 2014 Jun 9.

Reproductive Medicine Centre, Jinan Military General Hospital, Jinan, China

Background: Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia.

Methods: Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method.

Results: Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P < 0.001), systolic blood pressure (P < 0.05) and homeostasis model assessment of insulin resistance (P < 0.001).

Conclusion: Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.

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http://dx.doi.org/10.1177/0004563214541247DOI Listing
March 2015
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References

(Supplied by CrossRef)

Vitoratos N et al.
J Pregnancy 2012

ACOG Committee on Practice Bulletins—Obstetrics et al.
Obstet Gynecol 2002

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