Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.

ACS Med Chem Lett 2011 Jan 18;2(1):43-7. Epub 2010 Oct 18.

Departments of Medicinal Chemistry.

We report the development and characterization of compound 22 (MK-5046), a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3). In pharmacological testing using diet-induced obese mice, compound 22 caused mechanism-based, dose-dependent reductions in food intake and body weight.

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http://dx.doi.org/10.1021/ml100196dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018145PMC
January 2011
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