ACS Med Chem Lett 2011 Jan 18;2(1):43-7. Epub 2010 Oct 18.
Departments of Medicinal Chemistry.
We report the development and characterization of compound 22 (MK-5046), a potent, selective small molecule agonist of BRS-3 (bombesin receptor subtype-3). In pharmacological testing using diet-induced obese mice, compound 22 caused mechanism-based, dose-dependent reductions in food intake and body weight.