Search Our Scientific Publications & Authors

Hear Res 2022 May 11;420:108517. Epub 2022 May 11.

Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, Washington DC 20057, USA.

Tinnitus is a highly prevalent, largely untreatable auditory disorder, characterized by the perception of phantom sound often in the form of incessant ringing or hissing. Despite longstanding research with animal models, its underlying pathophysiological causes remain poorly understood. Given recent data characterizing tinnitus as a disorder with a strong neurocognitive component, progress in the field might be hastened by testing a wider spectrum of animal models, including nonhuman primates, and by developing alternative measurement techniques of tinnitus, especially in animals. Read More

Psychopharmacology (Berl) 2022 Apr 15. Epub 2022 Apr 15.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 410 North 12th Street, Room 746D, Richmond, VA, 23298-0613, USA.

Rationale: Rapidly evolving e-cigarette technology developed for self-administering nicotine aerosol has the potential to be utilized to self-administer other aerosolized drugs of abuse. Rodent models which mirror characteristics of human e-cigarette use are necessary to explore the degree to which this may be a public health concern.

Objectives: Our goal was to develop a highly translational model of discrete nose-only aerosol puff drug delivery to explore the reinforcing effects of fentanyl and sufentanil aerosols in rats. Read More

Toxicol In Vitro 2022 Mar 24;82:105352. Epub 2022 Mar 24.

Altria Client Services LLC, Richmond, VA, United States of America.

Air-liquid-interface (ALI) exposure systems deliver aerosol to the apical surface of cells which mimics the in vivo inhalation exposure conditions. It is necessary, however, to quantify the delivered amount of aerosol for ALI-based in vitro toxicity assessment. In this study, we evaluated two commercially available ALI exposure systems, a Vitrocell® Ames 48 (Ames 48) and a Vitrocell® 24/48 (VC 24/48), and the Vitrocell® VC1/7 smoking machine using a cig-a-like cartridge-based e-vapor device with a prototype formulation (containing 4% nicotine by weight). Read More

Int J Environ Res Public Health 2022 03 17;19(6). Epub 2022 Mar 17.

Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90039, USA.

Background: Exposure to air pollution is associated with acute pediatric asthma exacerbations, including reduced lung function, rescue medication usage, and increased symptoms; however, most studies are limited in investigating longitudinal changes in these acute effects. This study aims to investigate the effects of daily air pollution exposure on acute pediatric asthma exacerbation risk using a repeated-measures design.

Methods: We conducted a panel study of 40 children aged 8-16 years with moderate-to-severe asthma. Read More

J Neurosci Methods 2022 May 13;374:109565. Epub 2022 Mar 13.

Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA. Electronic address:

Background: The rodent vibrissal (whisker) systcnsorimotor integration and active tactile sensing. Experiments on the vibrissal system often require highly repeatable stimulation of multiple whiskers and the ability to vary stimulation parameters across a wide range. The stimulator must also be easy to position and adjust. Read More