Eur J Neurosci 2014 Jul 5;40(1):2206-15. Epub 2014 Jun 5.
Institute of Pharmacology and Toxicology, University of Zurich, 190 Winterthurerstrasse, Zurich, Switzerland.
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Eur J Neurosci 2014 Jul;40(1):2205
Nuffield Laboratory of Ophthalmology, John Radcliffe Hospital, University of Oxford, Levels 5-6, West Wing, Headley Way, Oxford, OX3 9DU, UK.
Bipolar Disord 2013 Dec 14;15(8):824-31. Epub 2013 Nov 14.
Department of Psychiatry, Dalhousie University, Halifax, NS.
Objectives: Abnormalities of signal transduction are considered among the susceptibility factors for bipolar disorder (BD). These include changes in G-protein-mediated signaling and subsequent modification of gene expression via transcription factors such as cAMP response element-binding protein (CREB).
Methods: We investigated levels of CREB in lymphoblasts from patients with BD, all responders to lithium prophylaxis (n = 13), and healthy control subjects (n = 15). Read More
J Neurochem 2000 Jun;74(6):2478-89
Dr. Senckenbergische Anatomie, Department of Anatomy II, Johann Wolfgang Goethe University Frankfurt, Germany.
Signal transduction processes regulating melatonin production in the light-sensitive trout pineal organ were investigated by immunocytochemical and immunochemical demonstration of phosphorylated cyclic AMP-responsive element-binding protein (pCREB) and measurements of cyclic AMP, melatonin, and calcium levels. Melatonin levels were tightly controlled by light and darkness. Elevation of cyclic AMP levels by 8-bromo-cyclic AMP, forskolin, and 3-isobutyl-1-methylxanthine increased the levels of pCREB and melatonin in light- or dark-adapted pineal organs in vitro. Read More
J Biol Chem 2000 Nov;275(44):34433-41
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA.
Two major intracellular signals that regulate neuronal function are calcium and cAMP. In many cases, the actions of these two second messengers involve long term changes in gene expression. One well studied target of both calcium and cAMP signaling is the transcription factor cAMP-responsive element-binding protein (CREB). Read More