Search our Database of Scientific Publications and Authors

I’m looking for a
    Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
    Curr Top Med Chem 2014 ;14(12):1418-24
    Escape Therapeutics, Inc., 5941 Optical Court, San Jose, CA 95138, USA.
    Short sequence amino acids or oligopeptides have recently garnered attention for use as treatments for a myriad of dermatologic disorders due to their ability to effect and modulate various biological processes in the epidermis and dermis, rendering them promising candidates as medical and cosmeceutical therapeutics. Major advantages include their relative ease of synthesis and multitude of modifications that can be applied to enhance potency, affinity, specificity, hydrophilicity or hydrophobicity and cytotoxicity. Given the photoprotective effects of eumelanin on skin, there has been substantial interest in developing agents, particularly α-MSH analogs, that can induce 'sunless tanning' helping reduce risk of melanoma and non-melanoma skin cancer. In this mini review, we present some of the recent and leading peptide modulators of melanogenesis with relevant clinical data and medical indications. Short sequence oligopeptides with tyrosinase inhibitory activity that can significantly reduce hyperpigmentation, as well α-MSH analogs that can enhance eumelanogenesis, are currently being clinically tested for treatment of erythropoietic protoporphyria, polymorphous light eruption, solar urticaria, actinic keratosis, and "sunless tanning". Success in developing such products can help reduce the incidence of skin cancer, one that surpasses that of all other human cancers combined.

    Similar Publications

    Novel pentapeptide activators of mammalian and mushroom tyrosinase.
    Curr Top Med Chem 2014 ;14(12):1463-8
    Escape Therapeutics, Inc., 5941 Optical Court, San Jose, CA 95138, USA.
    Melanoma incidence continues to rise due to intentional exposure to ultraviolet radiation (UVR) from sunlight and indoor tanning beds. Eumelanin exhibits photoprotective effects; thus, agents that induce its synthesis offer a means for sunless tanning without UVR damage. Herein, we report the development of two pentapeptides, P9 and P10, capable of enhancing melanin synthesis in B16 melanoma cells by activating mushroom and mouse tyrosinases without any effect on cell viability or proliferation. Read More
    The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine.
    Biomaterials 2014 May 3;35(15):4508-16. Epub 2014 Mar 3.
    Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-Ku, Okayama 700-8558, Japan.
    Topical therapy is the most favored form of treatment for whitening against hyper-pigmentation and sunburn because it lends itself to self-administration, patient compliance and an absence of systemic adverse effects. However, high-molecular-weight, hydrophilic chemicals are difficult to use as transdermal delivery drugs and the use of topical drugs has been highly limited. There are now many potent tyrosinase inhibitors, for example, sulfite or kojic acid, but the efficacy of their skin transduction remains a big problem. Read More
    The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches.
    Int J Cosmet Sci 2011 Jun 25;33(3):210-21. Epub 2011 Jan 25.
    Oriflame Cosmetics Skin Research Institute, SE-101 39 Stockholm, Sweden.
    Skin-lightening products are commercially available for cosmetic purposes to obtain lighter skin complexion. Clinically, they are also used for treatment of hyperpigmentary disorders such as melasma, café au lait spot and solar lentigo. All of these target naturally melanin production, and many of the commonly used agents are known as competitive inhibitors of tyrosinase, one of the key enzymes in melanogenesis. Read More
    Novel peptides with tyrosinase inhibitory activity.
    Peptides 2007 Mar 22;28(3):485-95. Epub 2007 Jan 22.
    Laboratory of Biochemistry, Wageningen University, P.O. Box 9101, 6700 HB Wageningen, The Netherlands.
    Tyrosinase inhibition by peptides may find its application in food, cosmetics or medicine. In order to identify novel tyrosinase inhibitory peptides, protein-based peptide libraries made by SPOT synthesis were used to screen for peptides that show direct interaction with tyrosinase. One of the peptide libraries studied consists of overlapping, octameric peptides derived from industrial proteins as beta-casein, alpha-lactalbumin, beta-lactoglobulin, ovalbumin, gliadin, glycinin, and beta-conglycinin. Read More