Extracellular entrapment and degradation of single-walled carbon nanotubes.

Authors:
Consol Farrera
Consol Farrera
Institute for Research in Biomedicine
Spain
Kunal Bhattacharya
Kunal Bhattacharya
Dublin Institute of Technology
Ireland
Kjell Hultenby
Kjell Hultenby
Karolinska Institutet
Sweden
Dr. Gregg P Kotchey, PhD
Dr. Gregg P Kotchey, PhD
University of Pittsburgh
Analytical Chemistry and Nanoscience
Pittsburgh, PA | United States
Alexander Star
Alexander Star
University of Pittsburgh
United States
Bengt Fadeel
Bengt Fadeel
Karolinska Institutet
Sweden

Nanoscale 2014 Jun;6(12):6974-83

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

Neutrophils extrude neutrophil extracellular traps (NETs) consisting of a network of chromatin decorated with antimicrobial proteins to enable non-phagocytic killing of microorganisms. Here, utilizing a model of ex vivo activated human neutrophils, we present evidence of entrapment and degradation of carboxylated single-walled carbon nanotubes (SWCNTs) in NETs. The degradation of SWCNTs was catalyzed by myeloperoxidase (MPO) present in purified NETs and the reaction was facilitated by the addition of H2O2 and NaBr. These results show that SWCNTs can undergo acellular, MPO-mediated biodegradation and imply that the immune system may deploy similar strategies to rid the body of offending microorganisms and engineered nanomaterials.

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June 2014
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