J Radiat Res 2014 Sep 15;55(5):948-58. Epub 2014 May 15.
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.
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Radiat Oncol 2014 Nov 11;9:238. Epub 2014 Nov 11.
Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.
Background: To moving lung tumors, we applied a respiratory-gated strategy to carbon-ion pencil beam scanning with multiple phase-controlled rescanning (PCR). In this simulation study, we quantitatively evaluated dose distributions based on 4-dimensional CT (4DCT) treatment planning.
Methods: Volumetric 4DCTs were acquired for 14 patients with lung tumors. Read More
Phys Med Biol 2016 05 21;61(10):3857-66. Epub 2016 Apr 21.
Department of Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
To shorten treatment time in pencil beam scanning irradiation, we developed rapid phase-controlled rescanning (rPCR), which irradiates two or more isoenergy layers in a single gating window. Here, we evaluated carbon-ion beam dose distribution with rapid and conventional PCR (cPCR). 4 dimensional computed tomography (4DCT) imaging was performed on 12 subjects with lung or liver tumors. Read More
Med Phys 2013 Mar;40(3):031720
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan.
Purpose: Irradiation of a moving target with a scanning beam requires a comprehensive understanding of organ motion as well as a robust dose error mitigation technique. The authors studied the effects of intrafractional respiratory motion for carbon-ion pencil beam scanning with phase-controlled rescanning on dose distributions for lung tumors. To address density variations, they used 4DCT data. Read More
Int J Radiat Oncol Biol Phys 2016 May 20;95(1):258-66. Epub 2016 Jan 20.
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
Purpose: Having implemented amplitude-based respiratory gating for scanned carbon-ion beam therapy, we sought to evaluate its effect on positional accuracy and throughput.
Methods And Materials: A total of 10 patients with tumors of the lung and liver participated in the first clinical trials at our center. Treatment planning was conducted with 4-dimensional computed tomography (4DCT) under free-breathing conditions. Read More