Search our Database of Scientific Publications and Authors

I’m looking for a
    Aerobic exercise and attention deficit hyperactivity disorder: brain research.
    Med Sci Sports Exerc 2015 Jan;47(1):33-9
    1Department of Sports, Chung-Ang University, Anseong, REPUBLIC OF KOREA; 2Department of Psychiatry, Chung-Ang University Hospital, Seoul, REPUBLIC OF KOREA; and 3Brain Institute, Department of Psychiatry, University of Utah, Salt Lake City, UT.
    Purpose: As adjuvant therapy for enhancing the effects of stimulants and thereby minimizing medication doses, we hypothesized that aerobic exercise might be an effective adjunctive therapy for enhancing the effects of methylphenidate on the clinical symptoms, cognitive function, and brain activity of adolescents with attention deficit hyperactivity disorder (ADHD).

    Methods: Thirty-five adolescents with ADHD were randomly assigned to one of two groups in a 1/1 ratio; methylphenidate treatment + 6-wk exercise (sports-ADHD) or methylphenidate treatment + 6-wk education (edu-ADHD). At baseline and after 6 wk of treatment, symptoms of ADHD, cognitive function, and brain activity were evaluated using the Dupaul attention deficit hyperactivity disorder rating scale--Korean version (K-ARS), the Wisconsin Card Sorting Test, and 3-T functional magnetic resonance imaging, respectively.

    Results: The K-ARS total score and perseverative errors in the sports-ADHD group decreased compared with those in the edu-ADHD group. After the 6-wk treatment period, the mean β value of the right frontal lobe in the sports-ADHD group increased compared with that in the edu-ADHD group. The mean β value of the right temporal lobe in the sports-ADHD group decreased. However, the mean β value of the right temporal lobe in the edu-ADHD group did not change. The change in activity within the right prefrontal cortex in all adolescents with ADHD was negatively correlated with the change in K-ARS scores and perseverative errors.

    Conclusions: The current results indicate that aerobic exercise increased the effectiveness of methylphenidate on clinical symptoms, perseverative errors, and brain activity within the right frontal and temporal cortices in response to the Wisconsin card sorting test stimulation.

    Similar Publications

    Common and unique therapeutic mechanisms of stimulant and nonstimulant treatments for attention-deficit/hyperactivity disorder.
    Arch Gen Psychiatry 2012 Sep;69(9):952-61
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
    CONTEXT Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and impairing psychiatric disorder that affects both children and adults. There are Food and Drug Administration-approved stimulant and nonstimulant medications for treating ADHD; however, little is known about the mechanisms by which these different treatments exert their therapeutic effects. OBJECTIVE To contrast changes in brain activation related to symptomatic improvement with use of the stimulant methylphenidate hydrochloride vs the nonstimulant atomoxetine hydrochloride. Read More
    Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.
    Biol Psychiatry 2014 Oct 24;76(8):616-28. Epub 2013 Oct 24.
    Fundació per a la Investigació i la Docència Maria Angustias Giménez Research Unit, Germanes Hospitalaries and Centro de Investigación Biomédica en Red de Salud Mental (JR), Barcelona, Spain.
    Background: Psychostimulant medication, most commonly the catecholamine agonist methylphenidate, is the most effective treatment for attention-deficit/hyperactivity disorder (ADHD). However, relatively little is known on the mechanisms of action. Acute effects on brain function can elucidate underlying neurocognitive effects. Read More
    Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder.
    Am J Psychiatry 2006 Jun;163(6):1044-51
    Department of Child Psychiatry, Institute of Psychiatry, King's College, London, SE5 8AF, UK.
    Objective: A relatively small number of functional imaging studies of attention deficit hyperactivity disorder (ADHD) have shown abnormal prefrontal and striatal brain activation during tasks of motor response inhibition. However, the potential confound of previous medication exposure has not yet been addressed, and no functional imaging study exists to date on medication-naive children and adolescents with ADHD. The aim of this study was to investigate the neural substrates of a range of motor and cognitive inhibitory functions in a relatively large group of children and adolescents with ADHD who had never previously been exposed to medication. Read More
    Attention-deficit/hyperactivity disorder: cognitive evoked potential (P300) topography predicts treatment response to methylphenidate.
    Clin Neurophysiol 2004 Jan;115(1):188-93
    Attention Disorders Institute, 44199 Dequindre, Ste. 311, Troy, MI 48085, USA.
    Objective: Auditory cognitive evoked potential (P300) topography predicts robust response to the stimulant pemoline in patients with attention-deficit/hyperactivity disorder (ADHD). Patients with a right fronto-central to parietal (FC2:P4) auditory P300 amplitude ratio >0.5 respond robustly to pemoline, whereas others do not. Read More