Lab Chip 2014 Jul 9;14(13):2249-58. Epub 2014 May 9.
Biomedical Diagnostics Institute, Dublin City University, Glasnevin, Dublin 9, Ireland.
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Lab Chip 2012 Aug 13;12(16):2894-902. Epub 2012 Jun 13.
Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Glasnevin, Dublin 9, Ireland.
In this article we introduce a novel technology that utilizes specialized water dissolvable thin films for valving in centrifugal microfluidic systems. In previous work (William Meathrel and Cathy Moritz, IVD Technologies, 2007), dissolvable films (DFs) have been assembled in laminar flow devices to form efficient sacrificial valves where DFs simply open by direct contact with liquid. Here, we build on the original DF valving scheme to leverage sophisticated, merely rotationally actuated vapour barriers and flow control for enabling comprehensive assay integration with low-complexity instrumentation on "lab-on-a-disc" platforms. Read More
Chem Soc Rev 2015 Oct 2;44(17):6187-229. Epub 2015 Jun 2.
Hahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Centrifugal microfluidics has evolved into a mature technology. Several major diagnostic companies either have products on the market or are currently evaluating centrifugal microfluidics for product development. The fields of application are widespread and include clinical chemistry, immunodiagnostics and protein analysis, cell handling, molecular diagnostics, as well as food, water, and soil analysis. Read More
Biosens Bioelectron 2016 Feb 2;76:54-67. Epub 2015 Jul 2.
Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Centrifugal microfluidics has attracted much interest from academia as well as industry, since it potentially offers solutions for affordable, user-friendly and portable biosensing. A wide range of so-called fluidic unit operations, e.g. Read More
Biosens Bioelectron 2015 Jun 30;68:382-389. Epub 2014 Dec 30.
Biomedical Diagnostics Institute, National Center for Sensor Research, Dublin City University, Ireland; School of Physical Sciences, Dublin City University, Ireland. Electronic address:
An electrochemical Lab-on-a-Disc (eLoaD) platform for the automated quantification of ovarian cancer cells (SKOV3) from whole blood is reported. This centrifugal microfluidic system combines complex sample handling, i.e. Read More