Hepatoprotective Effects of Silybum marianum (Silymarin) and Glycyrrhiza glabra (Glycyrrhizin) in Combination: A Possible Synergy.

Authors:
Mahmood Rasool
Mahmood Rasool
Center of Excellence in Genomic Medicine Research (CEGMR)
Jeddah | Saudi Arabia
Javed Iqbal
Javed Iqbal
Quaid-i-Azam University
Islamabad | Pakistan
Arif Malik
Arif Malik
Institute of Molecular Biology and Biotechnology (IMBB)
Germany
Hafiza Sobia Ramzan
Hafiza Sobia Ramzan
University of Lahore
Pakistan
Muhammad Saeed Qureshi
Muhammad Saeed Qureshi
Institute of Molecular Biology and Biotechnology (IMBB)
Pakistan
Muhammad Asif
Muhammad Asif
Department of Biotechnology and Informatics
Pakistan
Mahmood Husain Qazi
Mahmood Husain Qazi
The University of Lahore
Lahore | Pakistan
Mohammad Amjad Kamal
Mohammad Amjad Kamal
King Fahd Medical Research Center
Jeddah | Saudi Arabia

Evid Based Complement Alternat Med 2014 25;2014:641597. Epub 2014 Mar 25.

Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Post Box No. 80216, Jeddah 21589, Saudi Arabia.

Oxidative stress, lipid peroxidation, and transaminase reactions are some of the mechanisms that can lead to liver dysfunction. A time-dependent study was designed to evaluate the ability of silymarin (SLN) and glycyrrhizin (GLN) in different dosage regimens to lessen oxidative stress in the rats with hepatic injury caused by the hepatotoxin carbon tetrachloride. Wistar male albino rats (n = 60) were randomly assigned to six groups. Group A served as a positive control while groups B, C, D, E, and F received a dose of CCl4 (50% solution of CCl4 in liquid paraffin, 2 mL/kg, intraperitoneally) twice a week to induce hepatic injury. Additionally, the animals received SLN and GLN in different doses for a period of six weeks. CCl4 was found to induce hepatic injury by significantly increasing serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and thiobarbituric acid reactive substances while decreasing total protein and the activities of reduced glutathione, superoxide dismutase, and catalase. Treatment with various doses of SLN and GLN significantly reduced ALT, AST, ALP, and TBARS levels and increased GSH, SOD, and CAT levels. Our findings indicated that SLN and GLN have hepatoprotective effects against oxidative stress of the liver.

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http://dx.doi.org/10.1155/2014/641597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984823PMC

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May 2014
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