Search Our Scientific Publications & Authors

J Acquir Immune Defic Syndr 2021 Apr 1. Epub 2021 Apr 1.

Epicentre, Médecins sans Frontières, Paris, France OCP, Médecins sans Frontières, Nairobi, Kenya OCP, Médecins sans Frontières, Homa Bay, Kenya OCB, Médecins sans Frontières, Kinshasa, DRC Kenya Medical Research Institute/Centre for Global Health Research, Kisumu, Kenya Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Southern African Medical Unit, Médecins sans Frontières, Cape Town, South Africa Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa OCP, Médecins sans Frontières, Paris, France.

Background: Patients hospitalized with advanced HIV have a high mortality risk. We assessed viremia and drug resistance amongst differentiated care services and explored whether expediting the switching of failing treatments may be justified.

Setting: Hospitals in the Democratic Republic of Congo (HIV hospital), and Kenya (general hospital including HIV care). Read More

Epileptic Disord 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatric Neurology, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Epilepsia partialis continua (EPC) is a form of focal motor status epilepticus, associated with multiple etiologies. Etiology-specific treatments, such as hemispherotomy for Rasmussen encephalitis, lesionectomy for focal cortical dysplasia, and metabolic correction for non-ketotic hyperglycemia, have proven to be efficacious in treating EPC, but, in general, EPC is difficult to treat and often drug-resistant, and there is little evidence to guide therapy. We report the successful treatment of EPC with perampanel in two pediatric patients. Read More

Adv Exp Med Biol 2021 ;1256:265-293

Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. The pathogenesis of AMD involves dysfunction and loss of the retinal pigment epithelium (RPE), a monolayer of cells that provide nourishment and functional support for the overlying photoreceptors. RPE cells in mammals are not known to divide, renew or regenerate in vivo, and in advanced AMD, RPE loss leads to degeneration of the photoreceptors and impairment of vision. Read More

Dysphagia 2021 Apr 12. Epub 2021 Apr 12.

Department of Speech and Language Pathology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Assessing mild oropharyngeal dysphagia (OD) raises the question where to draw the line between normal and pathological swallowing. There is a lack of clinical test methods appropriate in the subacute phase of recovery from dysphagia following stroke and other brain injuries. The aim of this pilot study was to investigate the diagnostic accuracy of a new test battery, called the Swallow Battery (SwaB), in relation to Fiberoptic Endoscopic Evaluation of Swallowing (FEES). Read More

Am J Hematol 2021 Apr 12. Epub 2021 Apr 12.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Venetoclax (Ven) combined with a hypomethylating agent (HMA) has now emerged as an effective treatment regimen for acute myeloid leukemia, in both de novo and relapsed/refractory setting. The current multicenter study retrospectively examined Ven+HMA treatment outcome among 32 patients (median age 69 years; 59% males) with blast-phase myeloproliferative neoplasm (MPN-BP). Pre-leukemic phenotype included essential thrombocythemia (ET)/post-ET myelofibrosis (34%), polycythemia vera (PV)/post-PV myelofibrosis (38%) and primary myelofibrosis (28%). Read More