Clinicodiagnostic features of tuberculous meningitis and the role of CSF PCR in early diagnosis: a study from north-west India.

Authors:
Ashok Panagariya
Ashok Panagariya
SMS Medical College
India
Dr. Tarun Ralot, MD,DM NEUROLOGY
Dr. Tarun Ralot, MD,DM NEUROLOGY
RNT MEDICAL COLLEGE
NEUROLOGY
udaipur, rajasthan | India
Bhawna Sharma
Bhawna Sharma
SMS Medical College
Jaipur | India
Parul Dubey
Parul Dubey
National Chemical Laboratory
Philadelphia | United States

J Indian Med Assoc 2013 May;111(5):309-12, 314

The objective of this study was to study the clinical features and laboratory profile including acid fast bacillus microscopy, cerebrospinal fluid (CSF) culture and M. tuberculosis polymerase chain reaction (PCR) for an early diagnosis of tuberculous meningitis. Fifty consecutive patients, fulfilling the clinical criteria of tuberculous meningitis, were included in the study. All patients were subjected to detailed clinical and laboratory evaluation and radiological tests. CSF acid fast bacillus microscopy, culture and PCR were carried out in all and results were analysed. Majority of the patients presented with fever, headache, vomiting and signs of meningeal Irritation. Ziehl-Neelsen staining for acid-fast bacillus was positive in 4% cases, culture in 18% cases and CSF PCR for Mycobacterium tuberculosis was positive in 68%. Miliary pattern on chest x-ray was seen in 16% and CNS tuberculomas were seen in 14% cases. The CSF PCR estimation in clinically suspected cases of tuberculous meningitis may be an extremely valuable test for early diagnosis and institution of specific therapy.

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May 2013
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