Targeting mitochondria as therapeutic strategy for metabolic disorders.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Antonietta Valeria Pascale
Antonietta Valeria Pascale
Università degli Studi di Salerno
Italy
Rosa Finelli
Rosa Finelli
University of Salerno
Fisciano | Italy
Anna Lisa Carillo
Anna Lisa Carillo
Università Federico II
Italy
Roberto Annunziata
Roberto Annunziata
Università Federico II
Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

ScientificWorldJournal 2014 13;2014:604685. Epub 2014 Mar 13.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy ; IRCCS Multimedica, Via Fantoli 16/15, 20138 Milano, Italy.

Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.

Download full-text PDF

Source
http://dx.doi.org/10.1155/2014/604685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976884PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
January 2015
7 Reads
13 Citations
1.220 Impact Factor

Publication Analysis

Top Keywords

mitochondrial dysfunction
12
metabolic disorders
12
targeting mitochondria
8
metabolic syndrome
8
dysfunction associated
8
metabolic
5
ir/diabetes metabolic
4
cardiovascular diseases
4
finally novel
4
syndrome cardiovascular
4
conditions ir/diabetes
4
pathological conditions
4
main mitochondrial
4
mutations main
4
therapeutic interventions
4
novel mechanisms
4
dysfunction pathological
4
mtdna mutations
4
diseases cancer
4
clinical scenario
4

References

(Supplied by CrossRef)
Article in Physiological Reviews
Physiological Reviews 1979
Article in Diabetes
Diabetes 2004
Article in Journal of Biomedical Science
Journal of Biomedical Science 2002
Article in European Journal of Biochemistry
European Journal of Biochemistry 1993

Similar Publications