Immunopotentiating properties of extracellular polysaccharide from Trametes hirsuta strain VKESR.

Authors:
Shenbhagaraman R
Shenbhagaraman R
University of Madras
India
Jenefar S
Jenefar S
University of Madras
India
Saravanamurali K
Saravanamurali K
King Institute of Preventive Medicine
Kaveri K
Kaveri K
King Institute of Preventive Medicine
India
Kaviyarasan V
Kaviyarasan V
University of Madras

Carbohydr Polym 2014 Jun 8;106:299-304. Epub 2014 Feb 8.

Centre for Advanced Studies in Botany, University of Madras, Chennai, India.

The effectiveness of extracellular polysaccharides isolated from Trametes hirsuta strain VKESR was evaluated for their immunostimulating properties by in vitro lymphocyte proliferation, phagocytic assay, NK cell activity and cytokine quantification. The splenocyte proliferation assay showed that the extracellular glucans found to have good stimulation index and enhances the NK cell mediated tumor killing. It promotes phagocytosis in treated macrophages in a dose dependent manner. Furthermore, the polysaccharides exhibit significant stimulatory effect on cytokines IL-2 and IFN-γ whereas the polysaccharide has moderate stimulatory effect pro-inflammatory cytokine TNF-α. These immunostimulating properties help in combating various diseases and could be a promising beginning for further research to study the role of extracellular polysaccharide on the host immune systems.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carbpol.2014.02.003DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
June 2014
46 Reads

Publication Analysis

Top Keywords

hirsuta strain
8
extracellular polysaccharide
8
trametes hirsuta
8
immunostimulating properties
8
strain vkesr
8
phagocytosis treated
4
promotes phagocytosis
4
treated macrophages
4
dose dependent
4
polysaccharides exhibit
4
manner polysaccharides
4
dependent manner
4
killing promotes
4
macrophages dose
4
mediated tumor
4
extracellular glucans
4
assay extracellular
4
proliferation assay
4
splenocyte proliferation
4
glucans good
4

Similar Publications