The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle.

Authors:
Po Hung Liu
Po Hung Liu
Kyoto Prefectural University of Medicine
Japan
Wataru Aoi
Wataru Aoi
Kyoto Prefectural University
Japan
Maki Takami
Maki Takami
Kyoto Prefectural University
Japan
Yuko Tanimura
Yuko Tanimura
University of Tsukuba
Japan
Yuji Naito
Yuji Naito
Kyoto Prefectural University of Medicine
Japan
Yoshito Itoh
Yoshito Itoh
Kyoto Prefectural University of Medicine
Japan
Toshikazu Yoshikawa
Toshikazu Yoshikawa
Kyoto Prefectural University of Medicine
Japan

J Clin Biochem Nutr 2014 Mar 19;54(2):86-9. Epub 2014 Feb 19.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.

Astaxanthin, a xanthophyll carotenoid, accelerates lipid utilization during aerobic exercise, although the underlying mechanism is unclear. The present study investigated the effect of astaxanthin intake on lipid metabolism associated with peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in mice. Mice were divided into 4 groups: sedentary, sedentary and astaxanthin-treated, exercised, and exercised and astaxanthin-treated. After 2 weeks of treatment, the exercise groups performed treadmill running at 25 m/min for 30 min. Immediately after running, intermuscular pH was measured in hind limb muscles, and blood was collected for measurements. Proteins were extracted from the muscle samples and PGC-1α and its downstream proteins were measured by western blotting. Levels of plasma fatty acids were significantly decreased after exercise in the astaxanthin-fed mice compared with those fed a normal diet. Intermuscular pH was significantly decreased by exercise, and this decrease was inhibited by intake of astaxanthin. Levels of PGC-1α and its downstream proteins were significantly elevated in astaxanthin-fed mice compared with mice fed a normal diet. Astaxanthin intake resulted in a PGC-1α elevation in skeletal muscle, which can lead to acceleration of lipid utilization through activation of mitochondrial aerobic metabolism.

Download full-text PDF

Source
http://jlc.jst.go.jp/DN/JST.JSTAGE/jcbn/13-110?lang=en&f
Publisher Site
http://dx.doi.org/10.3164/jcbn.13-110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947967PMC
March 2014
49 Reads

Publication Analysis

Top Keywords

decreased exercise
8
mice compared
8
astaxanthin intake
8
lipid utilization
8
fed normal
8
astaxanthin-fed mice
8
normal diet
8
skeletal muscle
8
downstream proteins
8
lipid metabolism
8
pgc-1α downstream
8
exercise
5
mice
5
pgc-1α
5
proteins elevated
4
groups performed
4
sedentary astaxanthin-treated
4
plasma fatty
4
running 25 m/min
4
levels pgc-1α
4

Similar Publications