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FASEB J 2022 May;36 Suppl 1

University of Western Ontario, London, ON.

L-type Ca channels govern smooth muscle [Ca ] and myogenic tone development through mechanisms traditionally tied to voltage control. While essential, questions remain as to whether voltage is the sole regulatory influence or whether L-type Ca channels are additionally mechanosensitive. In this context, this study defined whether and by what mechanisms pressure stimuli modulate L-type Ca channels in rodent (rat & mouse) resistance arteries. Read More

J Am Heart Assoc 2022 May 10:e025173. Epub 2022 May 10.

Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark.

Background Estimated pulse wave velocity (ePWV) calculated by equations using age and blood pressure has been suggested as a new marker of mortality and cardiovascular risk. However, the prognostic potential of ePWV during long-term follow-up in patients with symptoms of stable angina remains unknown. Methods and Results In this study, ePWV was calculated in 25 066 patients without diabetes, previous myocardial infarction (MI), stroke, heart failure, or valvular disease (mean age 63. Read More

Heart Surg Forum 2022 Mar 21;25(2):E204-E212. Epub 2022 Mar 21.

Department of CVTS, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Background: Surgical revascularization by coronary artery bypass grafting (CABG) is the gold standard treatment for coronary artery disease. But, in patients with severe left ventricular dysfunction (ischemic cardiomyopathy), the result of CABG is different from those with normal left ventricular function. The coronary artery disease pattern in the Indian subconti-nent is different from the western world, due to the diffuse nature of coronary involvement, the smaller size of native vessels, increased prevalence of diabetes mellitus and other risk factors, and more prevalence of severe left ventricular dysfunction. Read More

Nature 2022 05 27;605(7908):152-159. Epub 2022 Apr 27.

II. Medizinische Klinik und Poliklinik, Technische Universität München, Klinikum rechts der Isar, Munich, Germany.

Atherosclerotic plaques develop in the inner intimal layer of arteries and can cause heart attacks and strokes. As plaques lack innervation, the effects of neuronal control on atherosclerosis remain unclear. However, the immune system responds to plaques by forming leukocyte infiltrates in the outer connective tissue coat of arteries (the adventitia). Read More

Arterioscler Thromb Vasc Biol 2022 Apr 21:101161ATVBAHA122317491. Epub 2022 Apr 21.

Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Denmark. (L.G.L., M.J.D.).

Background: Materials extracted from atherosclerotic arteries can disclose data about the molecular pathology of cardiovascular disease, but obtaining such samples is complex and requires invasive surgery. To overcome this barrier, this study investigated whether angioplasty balloons inflated during standard percutaneous coronary interventions retain proteins from treated (dilated) atherosclerotic lesions and whether proteomic analysis of this material could provide data on lesion protein profiles and distinguish between patients with stable and unstable coronary artery disease.

Methods: Patients with ST-segment-elevation myocardial infarction and stable angina pectoris were subjected to routine percutaneous coronary interventions. Read More