Search Our Scientific Publications & Authors

Am J Pathol 2021 Feb 27. Epub 2021 Feb 27.

Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Bologna, Italy. Electronic address:

This review will focus on typical hemolytic uremic syndrome (HUS), a life-threatening sequela of human infections caused, particularly in children, by Shiga toxin-producing Escherichia coli strains (STEC). Thrombotic microangiopathy of the brain and the kidney is the endpoint of toxin action resulting in the hallmarks of HUS, i.e. Read More

JCI Insight 2021 Mar 2. Epub 2021 Mar 2.

Genomic Research Alliance for Transplantation (GRAfT), National Heart, Lung, and Blood Institute (NHLBI), Bethesda, United States of America.

Introduction: Coronavirus 2019 (COVID-19) clinical course is heterogeneous, ranging from mild to severe multi-organ failure and death. In this study, we analyzed cell-free DNA (cfDNA) as a biomarker of injury to define the sources of tissue injury that contribute to such different trajectories.

Methods: We conducted a multi-center prospective cohort study to enroll COVID-19 patients and collect plasma samples. Read More

Eur J Heart Fail 2021 Mar 2. Epub 2021 Mar 2.

Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

Aims: The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic clusters of HFpEF based on circulating biomarkers.

Methods And Results: We performed an unsupervised cluster analysis using 363 biomarkers from 429 patient with HFpEF. Read More