Is continuation of antiplatelets until coronary artery bypass safe in Asians?

Asian Cardiovasc Thorac Ann 2014 Oct 27;22(8):909-18. Epub 2014 Jan 27.

Department of Surgery, National University of Singapore, Singapore Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore

Background: Controversies have arisen about the risks of discontinuing antiplatelets prior to coronary artery bypass grafting.

Methods: We retrospectively studied the effects of different strategies of antiplatelet discontinuation prior to coronary artery bypass on perioperative bleeding and major adverse cardiovascular events in Asian patients in a single center in Singapore.

Results: 402 patients were divided into 4 groups: group A had no antiplatelets before surgery; antiplatelets were stopped for 5-7 days in group B; 2-4 days in group C; and 0-1 day in group D. Compared to group B, group D had longer intensive care unit stays and more intraoperative transfusions of blood (p = 0.006) and blood products (p < 0.05). The 1-year major adverse cardiovascular event rate was higher in groups A and D (p = 0.027). Stopping antiplatelets within 24 h of surgery was one of multiple independent predictors of intraoperative transfusion but not the 1-year major adverse cardiovascular event rate. Patients on aspirin alone had less intraoperative transfusion of platelets and postoperative minor bleeding than those on combined therapy.

Conclusion: Continuation of antiplatelets until 2 days before coronary artery bypass in Asian patients in our institution is unlikely to increase the risks of bleeding and perioperative transfusion. Taking antiplatelets within 24 h of surgery seems to be associated with a higher rate of 1-year major adverse cardiovascular events and bleeding, and an increased risk of blood product transfusion. Thirty-day and 1-year major adverse cardiovascular event rates were higher in patients without antiplatelet treatment.

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http://dx.doi.org/10.1177/0218492314521421DOI Listing
October 2014
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References

(Supplied by CrossRef)
Article in Circulation
Eagle KA et al.
Circulation 2004
Article in Vasc Health Risk Manag
Gao R et al.
Vasc Health Risk Manag 2010

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