Comparison of percutaneous coronary intervention (with drug-eluting stents) versus coronary artery bypass grafting in women with severe narrowing of the left main coronary artery (from the Women-Drug-Eluting stent for LefT main coronary Artery disease Registry).

Authors:
Gill Louise Buchanan
Gill Louise Buchanan
San Raffaele Scientific Institute
Milano | Italy
Alaide Chieffo
Alaide Chieffo
San Raffaele Scientific Institute
Milano | Italy
Emanuele Meliga
Emanuele Meliga
Interventional Cardiology Unit
Austin | United States
Roxana Mehran
Roxana Mehran
Icahn School of Medicine at Mount Sinai
United States
Seung-Jung Park
Seung-Jung Park
South Korea
Yoshinobu Onuma
Yoshinobu Onuma
Thoraxcenter
Netherlands
Piera Capranzano
Piera Capranzano
Ferrarotto Hospital
Catania | Italy
Marco Valgimigli
Marco Valgimigli
Bern University Hospital
Bern | Switzerland

Am J Cardiol 2014 Apr 31;113(8):1348-55. Epub 2014 Jan 31.

San Raffaele Scientific Institute, Milan, Italy.

Women typically present with coronary artery disease later than men with more unfavorable clinical and anatomic characteristics. It is unknown whether differences exist in women undergoing treatment for unprotected left main coronary artery (ULMCA) disease. Our aim was to evaluate long-term clinical outcomes in women treated with percutaneous coronary intervention (PCI) with drug-eluting stents versus coronary artery bypass grafting (CABG). All consecutive women from the Drug-Eluting stent for LefT main coronary Artery disease registry with ULMCA disease were analyzed. A propensity matching was performed to adjust for baseline differences. In total, 817 women were included: 489 (59.8%) underwent treatment with PCI with drug-eluting stents versus 328 (40.2%) with CABG. Propensity score matching identified 175 matched pairs, and at long-term follow-up there were no differences in all-cause (odds ratio [OR] 0.722, 95% confidence interval [CI] 0.357 to 1.461, p=0.365) or cardiovascular (OR 1.100, 95% CI 0.455 to 2.660, p=0.832) mortality, myocardial infarction (MI; OR 0.362, 95% CI 0.094 to 1.388, p=0.138), or cerebrovascular accident (CVA; OR 1.200, 95% CI 0.359 to 4.007, p=0.767) resulting in no difference in the primary study objective of death, MI, or CVA (OR 0.711, 95% CI 0.387 to 1.308, p=0.273). However, there was an advantage of CABG in major adverse cardiovascular and cerebrovascular events (OR 0.429, 95% CI 0.254 to 0.723, p=0.001), driven exclusively by target vessel revascularization (OR 0.185, 95% CI 0.079 to 0.432, p<0.001). In women with significant ULMCA disease, no difference was observed after PCI or CABG in death, MI, and CVA at long-term follow-up.

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http://dx.doi.org/10.1016/j.amjcard.2014.01.409DOI Listing

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April 2014
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