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Varicella zoster virus (VZV) in cerebral arteries of subjects at high risk for VZV reactivation.

Authors:
Maria A Nagel Nelly Khmeleva Alexander Choe Jose Gutierrez Don Gilden

J Neurol Sci 2014 Apr 8;339(1-2):32-4. Epub 2014 Feb 8.

Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

With a decline in varicella zoster virus (VZV)-specific cell-mediated immunity, VZV can reactivate, infect cerebral arteries and cause stroke. Previous studies of cerebral arteries from subjects without a history of transient ischemic attacks or stroke revealed no VZV DNA or VZV antigen; however, VZV DNA and VZV antigen were found in the cerebral arteries of a subject with diabetes, a known risk factor for VZV reactivation and zoster. The present study analyzed an additional 55 cerebral arteries from 18 subjects with co-morbidities that may increase risk of VZV reactivation: a history of alcohol abuse, tricyclic antidepressant intoxication, cocaine abuse, HIV or being over age 70 years. VZV antigen was detected in 24 (44%) cerebral arteries from 14 (78%) subjects.

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http://dx.doi.org/10.1016/j.jns.2014.01.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978617PMC
April 2014

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