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    Serum uric acid and the risk of mortality during 23 years follow-up in the Scottish Heart Health Extended Cohort Study.
    Atherosclerosis 2014 Apr 30;233(2):623-9. Epub 2014 Jan 30.
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA; Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Australia; The George Institute for Global Health, Australia. Electronic address:
    Background: Elevated uric acid is a prevalent condition with controversial health consequences. Observational studies disagree with regard to the relationship of uric acid with mortality, and with factors modifying this relationship.

    Objective: We examined the association of serum uric acid with mortality in 15,083 participants in the Scottish Heart Health Extended Cohort (SHHEC) Study.

    Methods: Serum uric acid was measured at study enrollment. Death was ascertained using both the Scottish death register and record linkage.

    Results: During a median follow-up of 23 years, there were 3980 deaths. In Cox proportional hazards models with sexes combined, those in the highest fifth of uric acid had significantly greater mortality (HR 1.18, 95% CI: 1.06, 1.31) compared with the second fifth, after adjustment for traditional cardiovascular risk factors. This relationship was modified by sex (P-interaction=0.002) with adjusted HRs of 1.69 (95% CI: 1.40, 2.04) and 0.99 (95% CI: 0.86, 1.14) in women and men, respectively. Compared with the second fifth, the highest fifth of uric acid was most associated with kidney-related death (HR: 2.08, 95% CI: 1.31, 3.32).

    Conclusion: Elevated uric acid is associated with earlier mortality, especially in women. Future studies should evaluate mechanisms for these interactions and explore the strong association with renal-related mortality.

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    Serum uric acid predicts cardiovascular mortality in male peritoneal dialysis patients with diabetes.
    Nutr Metab Cardiovasc Dis 2016 Jan 17;26(1):20-6. Epub 2015 Nov 17.
    Department of Nephrology, Key Laboratory of Nephrology, Ministry of Health, Guangdong Provincial Key Laboratory of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address:
    Background And Aims: Serum uric acid may predict mortality in diabetic patients and dialysis patients. However, the relationship between serum uric acid and prognosis in diabetic peritoneal dialysis (PD) patients is unclear.

    Methods And Results: We conducted a cohort study of 1278 incident PD patients, (mean age 47. Read More
    Relationship between serum uric acid and all-cause and cardiovascular mortality in patients treated with peritoneal dialysis.
    Am J Kidney Dis 2014 Aug 28;64(2):257-64. Epub 2013 Oct 28.
    Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. Electronic address:
    Background: Although serum uric acid level appears to be associated with mortality in individuals treated with hemodialysis, the relationship between serum uric acid level and death is uncertain in patients treated with peritoneal dialysis (PD).

    Study Design: Cohort study.

    Setting & Participants: 985 patients from a single PD center in South China followed up for a median of 25. Read More
    Uric acid is not an independent predictor of cardiovascular mortality in type 2 diabetes: a population-based study.
    Atherosclerosis 2012 Mar 26;221(1):183-8. Epub 2011 Dec 26.
    Department of Internal Medicine, University of Torino, Italy.
    Objective: Although some studies have suggested that uric acid is a risk factor for mortality, this relationship is still uncertain in people with type 2 diabetes.

    Methods: The study base was the population-based cohort of 1540 diabetic subjects (median age 68.9 years) of the Casale Monferrato Study. Read More
    Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey.
    JAMA 2000 May;283(18):2404-10
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Context: Although many epidemiological studies have suggested that increased serum uric acid levels are a risk factor for cardiovascular mortality, this relationship remains uncertain.

    Objective: To determine the association of serum uric acid levels with cardiovascular mortality.

    Design And Setting: Cross-sectional population-based study of epidemiological follow-up data from the First National Health and Nutrition Examination Survey (NHANES I) from 1971-1975 (baseline) and data from NHANES I Epidemiologic Follow-up Study (NHEFS). Read More