Atrial fibrillation and microRNAs.

Authors:
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Gianluigi Condorelli
Gianluigi Condorelli
Humanitas Clinical and Research Center
Rozzano | Italy

Front Physiol 2014 24;5:15. Epub 2014 Jan 24.

Humanitas Clinical and Research Center Rozzano (Milan), Italy ; University of Milan Milan, Italy.

Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

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http://dx.doi.org/10.3389/fphys.2014.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900852PMC
June 2014
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45 Citations

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