Muscle-strengthening and conditioning activities and risk of type 2 diabetes: a prospective study in two cohorts of US women.

Authors:
An Pan
An Pan
School of Public Health
United States
Rania A Mekary
Rania A Mekary
MCPHS University
Boston | United States
Meir Stampfer
Meir Stampfer
Harvard T.H. Chan School of Public Health
Boston | United States
Walter C Willett
Walter C Willett
Harvard T.H. Chan School of Public Health
Boston | United States
Joann E Manson
Joann E Manson
Harvard Medical School
Boston | United States
Frank B Hu
Frank B Hu
Harvard T.H. Chan School of Public Health
United States

PLoS Med 2014 Jan 14;11(1):e1001587. Epub 2014 Jan 14.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, United States of America ; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.

Background: It is well established that aerobic physical activity can lower the risk of type 2 diabetes (T2D), but whether muscle-strengthening activities are beneficial for the prevention of T2D is unclear. This study examined the association of muscle-strengthening activities with the risk of T2D in women.

Methods And Findings: We prospectively followed up 99,316 middle-aged and older women for 8 years from the Nurses' Health Study ([NHS] aged 53-81 years, 2000-2008) and Nurses' Health Study II ([NHSII] aged 36-55 years, 2001-2009), who were free of diabetes, cancer, and cardiovascular diseases at baseline. Participants reported weekly time spent on resistance exercise, lower intensity muscular conditioning exercises (yoga, stretching, toning), and aerobic moderate and vigorous physical activity (MVPA) at baseline and in 2004/2005. Cox regression with adjustment for major determinants for T2D was carried out to examine the influence of these types of activities on T2D risk. During 705,869 person years of follow-up, 3,491 incident T2D cases were documented. In multivariable adjusted models including aerobic MVPA, the pooled relative risk (RR) for T2D for women performing 1-29, 30-59, 60-150, and >150 min/week of total muscle-strengthening and conditioning activities was 0.83, 0.93, 0.75, and 0.60 compared to women reporting no muscle-strengthening and conditioning activities (p<0.001 for trend). Furthermore, resistance exercise and lower intensity muscular conditioning exercises were each independently associated with lower risk of T2D in pooled analyses. Women who engaged in at least 150 min/week of aerobic MVPA and at least 60 min/week of muscle-strengthening activities had substantial risk reduction compared with inactive women (pooled RR = 0.33 [95% CI 0.29-0.38]). Limitations to the study include that muscle-strengthening and conditioning activity and other types of physical activity were assessed by a self-administered questionnaire and that the study population consisted of registered nurses with mostly European ancestry.

Conclusions: Our study suggests that engagement in muscle-strengthening and conditioning activities (resistance exercise, yoga, stretching, toning) is associated with a lower risk of T2D. Engagement in both aerobic MVPA and muscle-strengthening type activity is associated with a substantial reduction in the risk of T2D in middle-aged and older women.

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http://dx.doi.org/10.1371/journal.pmed.1001587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891575PMC

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January 2014
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