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PLoS One 2021 5;16(3):e0247924. Epub 2021 Mar 5.

Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Huddinge, Sweden.

Fragility fracture of the hip is associated with reduced functional status and mortality. Poor self-rated health (SRH) might be such an indicator. Our aim was to study if SRH was associated with hip fractures and all-cause mortality within the next 10 years in community-dwelling older women. Read More

J Bone Miner Res 2021 Mar 5. Epub 2021 Mar 5.

Bioanalytical Facility, Biomedical Research Centre, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.

The standard treatment of primary hypoparathyroidism (hypoPT) with oral calcium supplementation and calcitriol (or an analog), intended to control hypocalcemia and hyperphosphatemia and avoid hypercalciuria, remains challenging for both patients and clinicians. In 2015, human parathyroid hormone (hPTH) (1-84) administered as a daily subcutaneous injection was approved as an adjunctive treatment in patients who cannot be well controlled on the standard treatments alone. This open-label study aimed to assess the safety and efficacy of an oral hPTH(1-34) formulation as an adjunct to standard treatment in adult subjects with hypoparathyroidism. Read More

Calcif Tissue Int 2021 Mar 5. Epub 2021 Mar 5.

Division of Endocrinology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.

Patients with anorexia nervosa (AN) often experience low bone mineral density (BMD) and increased fracture risk, with low body weight and decreased gonadal function being the strongest predictors of the observed bone mineral deficit and fractures. Other metabolic disturbances have also been linked to bone loss in this group of patients, including growth hormone resistance, low insulin-like growth factor-1 (IGF-1) concentrations, low leptin concentrations, and hypercortisolemia. However, these correlations lack definitive evidence of causality. Read More

J Sports Med Phys Fitness 2021 Mar 5. Epub 2021 Mar 5.

Federal University of Santa Catarina, Research Center in Kinanthropometry and Human Performance, Florianópolis, Brazil.

Introduction: Bone parameters are influenced by multiple factors. However, when comparing sports, few studies have considered the simultaneous interference of these factors in bone parameters.

Objective: To compare bone mineral density (BMD) and bone mineral content (BMC) between university athletes from different sports, according to sex. Read More

Bioact Mater 2021 Aug 3;6(8):2511-2522. Epub 2021 Feb 3.

Musculoskeletal Research Laboratory of Department of Orthopedics & Traumatology and Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Introduction: Magnesium (Mg) has a prophylactic potential against the onset of hyperlipidemia. Similar to statin, Mg is recommended as lipid-lowering medication for hypercholesterolemia and concomitantly exhibits an association with increased bone mass. The combination of statin with Mg ions (Mg) may be able to alleviate the high-fat diet (HFD)-induced bone loss and reduce the side-effects of statin. Read More