Oral health comparison between children with neutropenia and healthy controls.

Spec Care Dentist 2014 Jan-Feb;34(1):12-8. Epub 2012 Nov 22.

Staff Paediatric Dentist, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.

The purpose of this cross-sectional study was to assess and compare the oral health of children with neutropenia, who are under the active care of a hematologist in a designated marrow failure and myelodysplasia program, to a healthy control group. Children aged 6-18 with neutropenia attending the Marrow Failure and Myelodysplasia Program at SickKids Hospital and controls attending the Children's Clinic, Faculty of Dentistry, University of Toronto were asked to participate in the study consisting of a patient questionnaire followed by a dental and radiographic examination. Fifteen patients with neutropenia (mean age 12.14 ± 4.04 years) and 26 healthy controls (mean age 11.61 ± 3.82 years) participated in this study. Patients with neutropenia reported significantly increased mouth sores (p < .008) and bleeding gums while brushing (p < .001). The dmft/t score was significantly lower for the neutropenia group (p < .009). The clinical examination also showed that there were no statistically significant differences with respect to ulcerations, gingival recession, tooth mobility, gingival inflammation, periodontal bone loss, DMFT/T scores, plaque, and calculus levels. Preliminary data demonstrates that pediatric patients who are under the active care of a hematologist do not present with an increased risk of oral diseases.

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http://dx.doi.org/10.1111/j.1754-4505.2012.00299.xDOI Listing
October 2015
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Cyclic neutropenia: a literature review and report of case
Spencer et al.
J Dent Child 1985
Oral sequelae of chronic neutrophil defects: case report of a child with glycogen storage disease type 1b
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Pediatr Dent 1995

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