Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30.

Expert Rev Pharmacoecon Outcomes Res 2014 Feb 10;14(1):139-46. Epub 2013 Dec 10.

Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

Objective: To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients.

Methods: Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30).

Results: Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. In the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. In patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL.

Conclusion: Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.

Download full-text PDF

Source
http://dx.doi.org/10.1586/14737167.2014.864560DOI Listing
February 2014
34 Reads

Publication Analysis

Top Keywords

quality life
12
global health
8
qlq-c30 functional/symptom
8
bone metastases
8
patients brain
8
brain metastases
8
health status
8
role functioning
8
worse qol
8
financial problems
8
fatigue financial
8
functioning fatigue
8
eortc qlq-c30
8
functional/symptom scores
8
advanced cancer
8
predictive factors
8
domain questions
4
status domain
4
life advanced
4
questions 30results
4

Similar Publications