The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients.

Biomark Med 2014 ;8(1):15-27

Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK.

Schizophrenia is characterized by a wide spectrum of clinical manifestations, including strong effects on mood and behavior. Patients can also suffer from serious comorbidities including immune system or metabolic abnormalities. Recent advances using proteomic profiling approaches have increased our understanding of these molecular effects and have laid the groundwork for unraveling the heterogeneity of this broadly defined disease. These findings could lead to improved diagnosis and stratification of patients through identification of biochemically different disease subtypes and personalized medicine approaches. The inclusion of molecular signatures in psychiatry will be an important leap forward in providing more effective treatment of patients suffering from this debilitating disorder.

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm.13.83DOI Listing
July 2014

Publication Analysis

Top Keywords

diagnosis stratification
8
improved diagnosis
8
system metabolic
4
identification biochemically
4
immune system
4
patients identification
4
abnormalities advances
4
stratification patients
4
metabolic abnormalities
4
biochemically disease
4
disease subtypes
4
suffer serious
4
personalized medicine
4
subtypes personalized
4
serious comorbidities
4
advances proteomic
4
comorbidities including
4
including immune
4
proteomic profiling
4
broadly defined
4

Altmetric Statistics

Similar Publications