Synthesis, anticonvulsant and neurotoxicity evaluation of some newer N-(2-benzoylbenzofuran-3-yl)-3-(substituted)-propanamide analogs.

Authors:
Dr. Mehnaz Kamal, PhD
Dr. Mehnaz Kamal, PhD
College of Pharmacy, Prince Sattam Bin Abdulaziz University
Assistant Professor
Medicinal chemistry
Al Kharj, Riyadh | Saudi Arabia

Cent Nerv Syst Agents Med Chem 2013 ;13(3):159-65

Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh 226 026, India.

A series of 12, N-(2-benzoylbenzofuran-3-yl)-3-(substituted)-propanamide analogs was designed and synthesized to meet the pharmacophore requirement essential for anticonvulsant activity. All the compounds were characterized by IR, (1)H NMR and mass spectral data followed by their anticonvulsant evaluation according to the Antiepileptic Drug Development Program (ADD) protocol. The present study has proved the hypothesis concerning the pharmacophore model with essential binding sites. N-(2-benzoylbenzofuran-3-yl)-3-(4-(2-fluorophenyl)piperazin-1-yl) propanamide, 6h was found to be the most active compound in both maximal electroshock seizure (MES) and subcutaneous metrazol (scMET) seizure test at 30 and100 mg/kg respectively at 0.5 and 4.0 h.

Download full-text PDF

Source
December 2014
8 Reads

Publication Analysis

Top Keywords

n-2-benzoylbenzofuran-3-yl-3-substituted-propanamide analogs
8
protocol study
4
add protocol
4
study proved
4
proved hypothesis
4
pharmacophore model
4
concerning pharmacophore
4
hypothesis concerning
4
program add
4
development program
4
spectral data
4
mass spectral
4
nmr mass
4
data anticonvulsant
4
anticonvulsant evaluation
4
antiepileptic drug
4
evaluation antiepileptic
4
model essential
4
binding sites
4
metrazol scmet
4

Similar Publications