BMC Biophys 2013 Nov 16;6(1):14. Epub 2013 Nov 16.
Laboratory for Information and Decision Systems, Massachussets Institute of Technology, 77 Massachusetts Avenue Cambridge, MA 02139, USA.
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PLoS Comput Biol 2016 Nov 3;12(11):e1005152. Epub 2016 Nov 3.
Department of Electrical Engineering, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America.
Intracellular transport is an essential function in eucaryotic cells, facilitated by motor proteins-proteins converting chemical energy into kinetic energy. It is understood that motor proteins work in teams enabling unidirectional and bidirectional transport of intracellular cargo over long distances. Disruptions of the underlying transport mechanisms, often caused by mutations that alter single motor characteristics, are known to cause neurodegenerative diseases. Read More
PLoS Comput Biol 2011 May 5;7(5):e1002032. Epub 2011 May 5.
Department of Physics and Astronomy, University of California, Irvine, Irvine, California, United States of America.
The spatial organization of the cell depends upon intracellular trafficking of cargos hauled along microtubules and actin filaments by the molecular motor proteins kinesin, dynein, and myosin. Although much is known about how single motors function, there is significant evidence that cargos in vivo are carried by multiple motors. While some aspects of multiple motor function have received attention, how the cargo itself--and motor organization on the cargo--affects transport has not been considered. Read More
PLoS One 2013 14;8(2):e54298. Epub 2013 Feb 14.
Department of Physics and Astronomy, University of California Irvine, Irvine, California, United States of America.
How intracellular transport controls the probability that cargos switch at intersections between filaments is not well understood. In one hypothesis some motors on the cargo attach to one filament while others attach to the intersecting filament, and the ensuing tug-of-war determines which filament is chosen. We investigate this hypothesis using 3D computer simulations, and discover that switching at intersections increases with the number of motors on the cargo, but is not strongly dependent on motor number when the filaments touch. Read More
Phys Biol 2010 Nov 22;7(4):046009. Epub 2010 Nov 22.
Dpto de Física de la Materia Condensada and BIFI, Universidad de Zaragoza, 50009 Zaragoza, Spain.
We analyze theoretically the effects of excluded-volume interactions between motors on the dynamics of a cargo driven by multiple motors. The model considered shares much in common with others recently proposed in the literature, with the addition of direct interaction between motors and motor back steps. The cargo is assumed to follow a continuum Langevin dynamics, while individual motors evolve following a Monte Carlo algorithm based on experimentally accessible probabilities for discrete forward and backward jumps, and attachment and detachment rates. Read More