J Integr Bioinform 2013 Nov 14;10(3):230. Epub 2013 Nov 14.
Signal Processing Lab, IEETA and Department of Electronics, Telecommunications and Informatics, University of Aveiro, 3810-193 Aveiro, Portugal.
In this study we explore the potential of inter-STOP symbol distances for finding coding regions in DNA sequences. We use the distance between STOP symbols in the DNA sequence and a chi-square statistic to evaluate the nonhomogeneity of the three possible reading frames and the occurrence of one long distance in one of the frames. The results of this exploratory study suggest that inter-STOP symbol distances have strong ability to discriminate coding regions in prokaryotes and simple eukaryotes.