Two-photon-triggered drug delivery in cancer cells using nanoimpellers.

Authors:
Jonas Croissant
Jonas Croissant
Smart Hybrid Materials Laboratory
United States
Marie Maynadier
Marie Maynadier
NanoMedSyn
Montpellier | France
Audrey Gallud
Audrey Gallud
Nanosafety & Nanomedicine Laboratory
France
Jeff L Nyalosaso
Jeff L Nyalosaso
Institut Charles Gerhardt de Montpellier
Montpellier | France
Gaelle Derrien
Gaelle Derrien
South Africa
Clarence Charnay
Clarence Charnay
Université de Montpellier
France

Angew Chem Int Ed Engl 2013 Dec 7;52(51):13813-7. Epub 2013 Nov 7.

Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1, cc 1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05 (France).

A therapy of cancer cells: Two-photon-triggered camptothecin delivery with nanoimpellers was studied in MCF-7 breast cancer cells. A fluorophore with a high two-photon absorption cross-section was first incorporated in the nanoimpellers. Fluorescence resonance energy transfer (FRET) from the fluorophore to the azobenzene moiety was demonstrated.

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http://dx.doi.org/10.1002/anie.201308647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940420PMC

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December 2013
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