GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus.

Sci Rep 2013 Oct 29;3:3075. Epub 2013 Oct 29.

1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA [2] Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(-9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

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http://dx.doi.org/10.1038/srep03075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810676PMC
October 2013
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