Monitoring the mineralisation of bone nodules in vitro by space- and time-resolved Raman micro-spectroscopy.

Analyst 2014 Jan 24;139(1):55-8. Epub 2013 Oct 24.

School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD, UK.

Raman microscopy was used as a label-free method to study the mineralisation of bone nodules formed by mesenchymal stem cells cultured in osteogenic medium in vitro. Monitoring individual bone nodules over 28 days revealed temporal and spatial changes in the crystalline phase of the hydroxyapatite components of the nodules.

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Source
http://xlink.rsc.org/?DOI=C3AN01716H
Publisher Site
http://dx.doi.org/10.1039/c3an01716hDOI Listing
January 2014

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