Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.

Authors:
Matthew Frampton
Matthew Frampton
Institute of Cancer Research
United Kingdom
Peter Broderick
Peter Broderick
Institute of Cancer Research
United Kingdom
Hauke Thomsen, Dr.
Hauke Thomsen, Dr.
GeneWerk GmbH
Senior Bioinformatician
Bioinformatics, Biostatistics, Genetics
Heidelberg, Baden-Württemberg/Germany | Germany
Jayaram Vijayakrishnan
Jayaram Vijayakrishnan
Institute of Cancer Research
United Kingdom
Rosie Cooke
Rosie Cooke
Charing Cross Hospital
Victor Enciso-Mora
Victor Enciso-Mora
Institute of Cancer Research
United Kingdom

Nat Commun 2013 ;4:2549

Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

In addition to HLA, recent genome-wide association studies (GWASs) of Hodgkin's lymphoma (HL) have identified susceptibility loci for HL at 2p16.1, 8q24.21 and 10p14. In this study, we perform a GWAS meta-analysis with published GWAS (totalling 1,465 cases and 6,417 controls of European background), and follow-up the most significant association signals in 2,024 cases and 1,853 controls. A combined analysis identifies new HL susceptibility loci mapping to 3p24.1 (rs3806624; P=1.14 × 10(-12), odds ratio (OR)=1.26) and 6q23.3 (rs7745098; P=3.42 × 10(-9), OR=1.21). rs3806624 localizes 5' to the EOMES (eomesodermin) gene within a p53 response element affecting p53 binding. rs7745098 maps intergenic to HBS1L and MYB, a region previously associated with haematopoiesis. These findings provide further insight into the genetic and biological basis of inherited susceptibility to HL.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053363PMC
http://dx.doi.org/10.1038/ncomms3549DOI Listing

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May 2014
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