Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: evidence from a systematic review.

Authors:
Lisa-Jane Keegan
Lisa-Jane Keegan
University of Leeds
United Kingdom
Rosa Reed-Berendt
Rosa Reed-Berendt
University of Leeds
United Kingdom
Deborah Murdoch-Eaton
Deborah Murdoch-Eaton
University of Leeds
United Kingdom

Dev Neurorehabil 2014 Oct 8;17(5):355-62. Epub 2013 Oct 8.

Programme in Clinical Psychology, Leeds Institute of Health Sciences, University of Leeds , Clarendon Road, Leeds LS2 9LJ , UK.

Objective: To retrieve and review all the relevant literature describing the administration of melatonin to treat impaired sleep in children following acquired brain injury (ABI).

Methods: A systematic search and retrieval of the literature was conducted using advanced search techniques. The retrieval identified 589 papers, seven of which were relevant. Review/outcomes criteria were developed and study quality was determined.

Results: There is paucity of high-quality evidence to support use of melatonin for sleep impairment post paediatric ABI. Variation in dosage, screening and outcome measures, data reporting and a lack of impairment delineation and treatment stratification were recurrent themes.

Conclusion: Retrieved evidence for the effectiveness of melatonin for post paediatric ABI sleep impairment appears promising. There is a clear need for further study in this area to inform clinical and research practices. Recommendations are given.

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http://dx.doi.org/10.3109/17518423.2012.741147DOI Listing

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October 2014
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