Effectiveness of melatonin for sleep impairment post paediatric acquired brain injury: evidence from a systematic review.

Authors:
Lisa-Jane Keegan
Lisa-Jane Keegan
University of Leeds
United Kingdom
Rosa Reed-Berendt
Rosa Reed-Berendt
University of Leeds
United Kingdom
Deborah Murdoch-Eaton
Deborah Murdoch-Eaton
University of Leeds
United Kingdom

Dev Neurorehabil 2014 Oct 8;17(5):355-62. Epub 2013 Oct 8.

Programme in Clinical Psychology, Leeds Institute of Health Sciences, University of Leeds , Clarendon Road, Leeds LS2 9LJ , UK.

Objective: To retrieve and review all the relevant literature describing the administration of melatonin to treat impaired sleep in children following acquired brain injury (ABI).

Methods: A systematic search and retrieval of the literature was conducted using advanced search techniques. The retrieval identified 589 papers, seven of which were relevant. Review/outcomes criteria were developed and study quality was determined.

Results: There is paucity of high-quality evidence to support use of melatonin for sleep impairment post paediatric ABI. Variation in dosage, screening and outcome measures, data reporting and a lack of impairment delineation and treatment stratification were recurrent themes.

Conclusion: Retrieved evidence for the effectiveness of melatonin for post paediatric ABI sleep impairment appears promising. There is a clear need for further study in this area to inform clinical and research practices. Recommendations are given.

Download full-text PDF

Source
http://dx.doi.org/10.3109/17518423.2012.741147DOI Listing
October 2014
9 Reads
1 PubMed Central Citation(source)
1.48 Impact Factor

Publication Analysis

Top Keywords

post paediatric
12
sleep impairment
12
effectiveness melatonin
8
paediatric abi
8
acquired brain
8
impairment post
8
brain injury
8
melatonin sleep
8
paucity high-quality
4
evidence support
4
high-quality evidence
4
determinedresults paucity
4
abi variation
4
screening outcome
4
dosage screening
4
variation dosage
4
quality determinedresults
4
support melatonin
4
review/outcomes criteria
4
retrieval identified
4

Similar Publications

The use of MElatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS).

Health Technol Assess 2012 ;16(40):i-239

Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Background: Difficulties in initiating and maintaining sleep are common in children with neurodevelopmental disorders. Melatonin is unlicensed in children yet widely prescribed for sleep problems.

Objective: To determine whether or not immediate-release melatonin is beneficial compared with placebo in improving total duration of night-time sleep in children with neurodevelopmental problems. Read More

View Article
March 2013

Interventions with a sleep outcome for children with cerebral palsy or a post-traumatic brain injury: a systematic review.

Sleep Med Rev 2012 Dec 18;16(6):561-73. Epub 2012 May 18.

Department of Women's & Children's Health, University of Otago, PO Box 913, Dunedin 9016, New Zealand.

The purpose of this study was to conduct a systematic literature review on interventions for sleep problems in children (aged 0-12 years) with cerebral palsy (CP) or traumatic brain injury (TBI). The literature describes sleep disorders as common in both conditions. Criteria were expanded to include interventions for other medical conditions where sleep was measured as an outcome. Read More

View Article
December 2012

Melatonin for non-respiratory sleep disorders in visually impaired children.

Cochrane Database Syst Rev 2011 Nov 9(11):CD008473. Epub 2011 Nov 9.

1School of Pharmacy, The University of Queensland, Brisbane, Australia.

Background: Exogenous melatonin helps in regulating the circadian rhythm and is widely used for the management of sleep disorders in visually impaired children.

Objectives: The aim of the review was to assess melatonin therapy for treatment of non-respiratory sleep disorders in visually impaired children, with regard to improvement in sleep habit, sleep scheduling and sleep maintenance, when compared with placebo or no treatment.

Search Methods: We searched the following databases between February 2011 and July 2011: the Cochrane Central Register of Controlled Trials (CENTRAL) 2011(1) searched on 4th February 2011; MEDLINE (1950 to June Week 3, 2011) searched on 20th June 2011; EMBASE (1980 to June Week 4, 2011) searched on 7th July 2011; CINAHL (1937 to 21 September 2011); the metaRegister of Controlled Trials (this includes ClinicalTrial. Read More

View Article
November 2011

Melatonin for disordered sleep in individuals with autism spectrum disorders: systematic review and discussion.

Sleep Med Rev 2011 Dec 9;15(6):379-87. Epub 2011 Mar 9.

CHU de Caen, Service de Psychiatrie de l'enfant et de l'adolescent, Avenue Clemenceau, Caen F-14000, France.

Sleep disturbance is common in autism spectrum disorders (ASD) and melatonin is widely prescribed in such cases despite a lack of guidelines. The aim of this paper is to provide a systematic review of efficacy and safety of exogenous melatonin for treating disordered sleep in individuals with ASD. We performed a Pubmed(®) documentary search enlarged by a manual review of references, which finally supplied 12 citations (4 case reports, 3 retrospective studies, 2 open-label clinical trials, and 3 placebo-controlled trials). Read More

View Article
December 2011