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Front Microbiol 2021 19;12:629163. Epub 2021 Mar 19.

Department of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Naples, Italy.

Our understanding of the function of bacterial carbonic anhydrases (CAs, EC 4.2.1. Read More

Int J Mol Sci 2021 Mar 20;22(6). Epub 2021 Mar 20.

Department of Biology, University of Kaiserslautern, D-67653 Kaiserslautern, Germany.

Intra- and extracellular pH regulation is a pivotal function of all cells and tissues. Net outward transport of H is a prerequisite for normal physiological function, since a number of intracellular processes, such as metabolism and energy supply, produce acid. In tumor tissues, distorted pH regulation results in extracellular acidification and the formation of a hostile environment in which cancer cells can outcompete healthy local host cells. Read More

Int J Mol Sci 2021 Mar 11;22(6). Epub 2021 Mar 11.

Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6140, South Africa.

Carbonic anhydrases (CAs) have been identified as ideal catalysts for CO sequestration. Here, we report the sequence and structural analyses as well as the molecular dynamics (MD) simulations of four γ-CAs from thermophilic bacteria. Three of these, , and originate from hydrothermal vents and one, HB8, from hot springs. Read More

Medicine (Baltimore) 2021 Mar;100(12):e24957

Department of General surgery, Affiliated Hospital of Nantong University, Nantong, China.

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is 1 of the highly fatal and most aggressive types of malignancies and accounts for the vast majority of Pancreatic Cancer. Numerous studies have reported that the tumor microenvironment (TME) was significantly correlated with the oncogenesis, progress, and prognosis of various malignancies. Therefore, mining of TME-related genes is reasonably important to improve the overall survival of patients with PDAC. Read More

Inorg Chem 2021 Apr 24;60(7):4744-4754. Epub 2021 Mar 24.

Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.

Sulfonamides have a broad range of therapeutic applications, which include the inhibition of various isoforms of carbonic anhydrases (CAs). Among the various CA isoforms, CA IX is overexpressed in tumors and regulates the pH of the tumor microenvironment. Herein we present five new ruthenium(II) -cymene complexes (-) of Schiff base ligands (-) of 4-(2-aminoethyl)benzenesulfonamide by varying the aldehyde to enhance the selective cytotoxicity toward cancer cells. Read More