Assessment of Parkinson's disease risk loci in Greece.

Neurobiol Aging 2014 Feb 27;35(2):442.e9-442.e16. Epub 2013 Sep 27.

Reta Lila Weston Laboratories and Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous risk variants pointing to novel pathways potentially implicated in the pathogenesis of PD. Contributing to these GWAS efforts, we performed genotyping of previously identified risk alleles in PD patients and control subjects from Greece. We showed that previously published risk profiles for Northern European and American populations are also applicable to the Greek population. In addition, although our study was largely underpowered to detect individual associations, we replicated 5 of 32 previously published risk variants with nominal p values <0.05. Genome-wide complex trait analysis revealed that known risk loci explain disease risk in 1.27% of Greek PD patients. Collectively, these results indicate that there is likely a substantial genetic component to PD in Greece, similarly to other worldwide populations, that remains to be discovered.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830580PMC
February 2014
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