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    Follicular Mucinosis Associated With Nonlymphoid Skin Conditions.
    Am J Dermatopathol 2013 Sep 20. Epub 2013 Sep 20.
    Departments of *Dermatology, and †Pathology, University Hospital of Salamanca, Paseo de San Vicente, Salamanca, Spain.
    Background:: Follicular mucinosis coexisting with lymphoproliferative disorders has been thoroughly debated. However, it has been rarely reported in association with inflammatory disorders.

    Methods:: Thirteen cases have been retrieved, and those with cutaneous lymphoma or alopecia mucinosa were excluded.

    Results:: It was found follicular mucinosis in the setting of squamous cell carcinoma, seborrheic keratosis, simple prurigo, acne vulgaris, dextrometorphan-induced phototoxicity, polymorphous light eruption (2 cases), insect bite (2 cases), tick bite, discoid lupus erythematosus, drug-related vasculitis, and demodecidosis. Unexpectedly, our observations revealed a preponderating accumulation of mucin related to photo-exposed areas, sun-associated dermatoses, and histopathologic solar elastosis. The amount of mucin filling the follicles apparently correlated with the intensity of perifollicular inflammatory infiltrate, which was present in all cases. The concurrence of dermal interstitial mucin was found in 7 cases (54%).

    Conclusions:: The concurrence of interstitial dermal mucinosis or the potential role of both ultraviolet radiation and the perifollicular inflammatory infiltrates in its pathogenesis deserves further investigations. Precise recognition and understanding of this distinctive reactive histological pattern may prevent our patients from unnecessary diagnostic and therapeutic strategies.

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    Follicular mucinosis associated with nonlymphoid skin conditions.
    Am J Dermatopathol 2014 Sep;36(9):705-9
    Departments of *Dermatology, and †Pathology, University Hospital of Salamanca, Salamanca, Spain.
    Background: Follicular mucinosis coexisting with lymphoproliferative disorders has been thoroughly debated. However, it has been rarely reported in association with inflammatory disorders.

    Methods: Thirteen cases have been retrieved, and those with cutaneous lymphoma or alopecia mucinosa were excluded. Read More
    [Alopecia mucinosa].
    Actas Dermosifiliogr 2006 Oct;97(8):514-7
    Servicio de Dermatología, Hospital Virgen Salud, Toledo, España.
    Epithelial mucinosis (follicular mucinosis) is a reactive histological pattern characterized by the accumulation of mucin in the infundibular, follicular, and sebaceous epithelium, that may occur in multiple skin conditions and cannot be considered a specific disease. Alopecia mucinosa is a clinicopathological entity with distinctive skin lesions, mucin deposits in the hair follicles and periadnexal lymphoid infiltrates. Three types of mucinous alopecia have been described: idiopathic, persistent or benign chronic, and associated to lymphoma. Read More
    [Cutaneous mucinosis].
    Ann Dermatol Venereol 1993 ;120(1):75-87
    Clinica Dermatologica, Università di Genova, Italie.
    The cutaneous mucinoses are a heterogeneous group of diseases in which mucin accumulates in the skin or within the hair follicle. We divide the cutaneous mucinoses into two groups: the distinctive cutaneous mucinoses in which the mucin deposit is a distinctive histopathologic feature that manifests as a clinically specific lesion, and the diseases associated with histopathologic mucin deposition as an additional finding. This article deals with the clinical and histopathologic features and the treatment of the distinctive cutaneous mucinoses and updates their classification. Read More
    Failure to detect clonality in eosinophilic pustular folliculitis with follicular mucinosis.
    Acta Derm Venereol 2004 ;84(4):305-7
    Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
    Eosinophilic pustular folliculitis is characterized by an eosinophil-rich inflammatory follicular and perifollicular infiltrate primarily centred at the level of the follicular isthmus and sebaceous duct. Follicular mucinosis has been observed in lesions of eosinophilic pustular folliculitis. Clinical and histological features of eosinophilic pustular folliculitis with follicular mucinosis and alopecia mucinosa are very similar. Read More