Dig Dis 2013 6;31(2):202-6. Epub 2013 Sep 6.
Division of Gastroenterology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ont., Canada.
No single test is diagnostic of Crohn's disease (CD). In the presence of a compatible clinical presentation, diagnosis is by convention confirmed by a combination of imaging, serologic, endoscopic and histologic investigations. This diagnostic recommendation should be maintained, even though histology is often 'compatible with' rather than 'diagnostic of' suspected CD. The importance of histology varies depending on the specific sites of macroscopic disease. Histology is particularly important in distinguishing type of inflammatory bowel disease, when the colon predominantly is involved, and in confirming CD when macroscopic disease is atypically located.