Uptake and positive predictive value of fecal occult blood tests: A randomized controlled trial.

Authors:
Laing Sharon S, PhD
Laing Sharon S, PhD
University of Washington Tacoma
Assistant Professor of Nursing and Healthcare Leadership
Tacoma, Washington | United States

Prev Med 2013 Nov 9;57(5):671-8. Epub 2013 Sep 9.

Group Health Research Institute, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA. Electronic address:

Objective: The aim of this study is to compare the uptake of three mailed high-sensitivity fecal occult blood tests (FOBTs).

Methods: We conducted a parallel 3-arm randomized controlled trial in an integrated healthcare delivery system in Washington State. From January 2010 through February 2011, automated data were used to identify potentially eligible patients aged 50-74 due for colorectal cancer screening. Participants were mailed one of three FOBT kits (1-sample OC-Auto® fecal immunochemical test [FIT], 2-sample InSure® FIT, or 3-sample guaiac Hemoccult SENSA®), instructions, and a postage-paid return envelope. We performed a modified intent-to-treat analysis with return of any FOBT within 6 months of randomization as the primary outcome.

Results: Of the 9922 people invited, 2873 returned surveys, 2263 were randomized, and 2234 were analyzed. FOBTs were returned by 1431 participants. At 6 months post-randomization, the proportions screened by any FOBT were 0.69 (95% confidence interval [CI] 0.66-0.72) for the OC-Auto arm, 0.64 (95% CI: 0.61-0.68) for the InSure arm, and 0.61 (95% CI: 0.58-0.65) for the Hemoccult SENSA arm (P<0.001 for any difference). Pairwise comparisons showed significant differences between the OC-Auto group and each of the other groups after correction for multiple comparisons.

Conclusion: Uptake of mailed FOBT kits varies by kit type.

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Source
http://dx.doi.org/10.1016/j.ypmed.2013.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856243PMC
November 2013
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10 Citations
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